Sequencing by Expansion - Meet the future of NGS

The next frontier of NGS is moving beyond traditional DNA sequencing technologies toward Sequencing by Expansion (SBX). By converting native DNA into a "surrogate" polymer called an Xpandomer, this technology overcomes the physical density of genetic material. Through precise molecular engineering, reporter codes are expanded to over 50 times the length of typical bases, dramatically improving signal resolution and reading speed.

This innovation utilizes highly engineered X-NTP building blocks and a specialized polymerase to synthesize the Xpandomer, ensuring robust, high-accuracy reads with flexible lengths. The process culminates in a CMOS-based sensor array that drives single-molecule measurement at incredible speeds, bypassing the delays of traditional cycle-based sequencing techniques. With the ability to move from sample to results in under four hours and a reusable sensor design that slashes costs, SBX is set to redefine clinical research.